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Case Report
Volume 1, Issue 1

Coexistence of a Malignant Phyllodes Tumor of the Breast with Heterologous Elements (Osteosarcoma and Chondrosarcoma) and Invasive Ductal Carcinoma: Case Report and Review of the Literature

Nicolas Ashjian1, Cynthia Mehrabi1, Lawrence Willes2, Lana Louie3 and Brian Dickinson1*

1Plastic and Reconstructive Surgery, 351 Hospital Road Suite 415, Newport Beach, CA, USA
2Adventist Health Glendale, 1509 Wilson Terrace, Glendale, CA, USA
3Breast Surgery, 18370 Burbank Blvd. Suite 607, Tarzana, CA, USA

*Corresponding author: Brian Dickinson, Plastic and Reconstructive Surgery (Private Practice), 351 Hospital Road Suite 415, Newport Beach, CA, USA.
E-mail: drdickinson@drbriandickinson.com

Received: September 21, 2025; Accepted: October 04, 2025; Published: October 15, 2025

Citation: Ashjian N, Mehrabi C, Dickinson B, et al. Coexistence of a Malignant Phyllodes Tumor of the Breast with Heterologous Elements (Osteosarcoma and Chondrosarcoma) and Invasive Ductal Carcinoma: Case Report and Review of the Literature. J Breast Cancer Case Rep. 2025; 1(1): 106.

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Abstract

Malignant phyllodes tumor (MPT) is a rare lesion in the female breast, representing less than 1% of all breast tumors. There have been case reports of coexistent breast carcinoma (both ductal and lobular carcinomas) with MPT. This coexistence has been shown to be associated with the malignant category of phyllodes tumors. Rarely, is breast carcinoma diagnosed preoperatively in the setting of MPT. We report a case of regionally metastatic MPT with heterologous components of osteosarcoma and chondrosarcoma with an incidental finding of an internal mammary lymph node positive for invasive ductal carcinoma while the axillary lymph nodes are positive for the sarcoma. This case is presented along with a literature review. The multidisciplinary breast care team must be aware of the coexistence of carcinoma and MPTs and consider a thoughtful treatment plan for extirpation and reconstruction with potential need for radiation and systemic therapy.

Keywords: Breast cancer; Phyllodes tumor; Breast cancer staging