A Rare Presentation of Radiation-Associated Angiosarcoma of the Breast Following Intraoperative Radiation Therapy

Case Report

Volume 2, Issue 1

A Rare Presentation of Radiation-Associated Angiosarcoma of the Breast Following Intraoperative Radiation Therapy

Ruth Samson^1*, Abigail Brooks², Fnu Sapna³ and Sheldon Feldman⁴

¹Department of Breast Surgery, Montefiore Medical Center, The University Hospital for Albert Einstein College of Medicine, Bronx, NY, USA
²Department of Surgery, Montefiore Medical Center, The University Hospital for Albert Einstein College of Medicine, Bronx, NY, USA
³Department of Breast Pathology, Montefiore Medical Center, The University Hospital for Albert Einstein College of Medicine, Bronx, NY, USA
⁴Chief, Division of Breast Surgery & Breast Surgical Oncology, Director, Breast Cancer Services, Montefiore Medical Center, Bronx, NY, USA

^*Corresponding author: Ruth Samson, Department of Breast Surgery, Montefiore Medical Center, The University Hospital for Albert Einstein College of Medicine, Bronx, NY, USA. E-mail: ruthsamsont@gmail.com

Received: May 28, 2026; Accepted: June 16, 2026; Published: June 25, 2026

Citation: Samson R, Brooks A, Sapna F, et al. A Rare Presentation of Radiation-Associated Angiosarcoma of the Breast Following Intraoperative Radiation Therapy. J Breast Cancer Case Rep. 2026; 2(1): 111.

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Abstract

Radiation-associated angiosarcoma of the breast (RAASB) is a rare but highly aggressive complication of breast-conserving therapy. It accounts for less than 1% of all breast malignancies and typically presents 5–10 years after radiation exposure [1,2]. Clinically, RAASB most often manifests as cutaneous lesions rather than a discrete breast mass, contributing to frequent diagnostic delays [3]. Although most reported cases follow whole-breast external beam radiation therapy, there is limited literature on RAASB after intraoperative radiation therapy (IORT) [4]. We report a rare case of angiosarcoma developing five years after lumpectomy with sentinel lymph node biopsy and IORT.

Keywords: Intraoperative radiation; IORT; Angiosarcoma of breast; Breast cancer; Case report

Article Details

A Rare Presentation of Radiation-Associated Angiosarcoma of the Breast Following Intraoperative Radiation Therapy